- Short Communication
- Published:
- AG Dulloo1,
- J Seydoux2,
- L Girardier2,
- P Chantre3 &
- …
- J Vandermander3
International Journal of Obesity volume24,pages 252–258 (2000)Cite this article
-
22k Accesses
-
301 Citations
-
150 Altmetric
-
Metrics details
Abstract
The thermogenic effect of tea is generally attributed to its caffeine content. We report here that a green tea extract stimulates brown adipose tissue thermogenesis to an extent which is much greater than can be attributed to its caffeine content per se, and that its thermogenic properties could reside primarily in an interaction between its high content in catechin-polyphenols and caffeine with sympathetically released noradrenaline (NA). Since catechin-polyphenols are known to be capable of inhibiting catechol-O-methyl-transferase (the enzyme that degrades NA), and caffeine to inhibit trancellular phosphodiesterases (enzymes that break down NA-induced cAMP), it is proposed that the green tea extract, via its catechin-polyphenols and caffeine, is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA–cAMP axis. Such a synergistic interaction between catechin-polyphenols and caffeine to augment and prolong sympathetic stimulation of thermogenesis could be of value in assisting the management of obesity.
This is a preview of subscription content, access via your institution
Access options
Change institution
Buy or subscribe
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Learn more
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
Article Open access 07 October 2022
The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial
Article Open access 24 September 2021
Effects of green tea and roasted green tea on human responses
Article Open access 13 April 2024
References
Landsberg L, Saville ME, Young JB . Sympathoadrenal system and regulation of thermogenesis Am J Physiol 1984 247: E181–E189.
CAS PubMed Google Scholar
Stock MJ . Experimental studies with selective beta-adrenergic agonists and antagonists in animals Int J Obes 1993 17 (Suppl 2): S69–72.
CAS Google Scholar
Dulloo AG . Spicing fat for combustion Br J Nutr 1998 80: 493–494.
Dulloo AG . Ephedrine, xanthines and prostaglandin-inhibitors: actions and interactions in the stimulation of thermogenesis Int J Obes 1993 17 (Suppl 1): S35–S40.
CAS Google Scholar
Toubro S, Astrup A, Breum L, Quaade F . Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture Int J Obes 1993 17 (Suppl 1): S69–72.
Daly P, Krieger D, Dulloo AG, Young JB, Landsberg L . Ephedrine, caffeine and aspirin: Safety and efficacy for the treatment of human obesity Int J Obes 1993 17 (Suppl 1): S73–S78.
Dulloo AG, Seydoux J, Girardier L . Peripheral mechanisms of thermogenesis induced by ephedrdine and caffeine in brown adipose tissue Int J Obes 1991 15: 317–326.
CAS PubMed Google Scholar
Dulloo AG, Seydoux J, Girardier L . Potentiation of the thermogenic antiobesity effects of ephedrine by dietary methylxanthines: Adenosine antagonism or phosphodiesterase inhibition? Metabolism 1992 41: 1233–1241.
Durand J, Giacobino JP, Girardier L . Catechol-O-methyl-transferase activity in whole brown adipose tissue of rate in vitro. In Girardier L, Seydoux J (eds) Effectors of thermogenesis. Birkhauser: Basel, 1977, pp 45–53.
Borchardt RT, Huber JA . Catechol O-methyltransferase: structure–activity relationships for inhibition by flavonoids J Med Chem 1975 18: 120–122.
Rhodes MJC . Physiologically-active compounds in plant foods: An overview Proc Nutr Soc 1996 55: 371–384.
Barde YA, Chinet A, Girardier L . Potassium-induced increase in oxygen consumption of brown adipose tissue from the rat J Physiol (Lond) 1975 252: 523–536.
Young JB, Saville E, Rothwell NJ, Stock MJ . Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat J Clin Invest 1982 69: 1061–1071.
Seydoux J, Mory G, Girardier L . Short-lived derivation of brown adipose tissue of the rat induced by chemical sympathetic denervation J Physiol (Paris) 1981 77: 1017–1022.
CAS Google Scholar
Seydoux J, Girardier L . Control of brown fat thermogenesis by the sympathetic nervous system. In Girardier L, Seydoux J (eds) Effectors of thermogenesis, Experientia Supplement no. 32. Birkhauser: Basel, 1977, pp 153–167.
Hertog MGL . Epidemiological evidence on potential health properties of flavonoids Proc Nutr Soc 1996 55: 385–397.
Kannar ML, Wahlqvist ML, O'Brien RC . Inhibition of LDL oxidation by green tea extract Lancet 1997 349: 360–361.
Jankun J, Selman SH, Swiercz R . Why drinking green tea could prevent cancer Nature 1997 387: 561.
Stagg GV, Millin DJ . The nutritional and therapeutic value of tea—a review J Sci Fd Agric 1975 26: 1439–1459.
Hollman PCH . Bioavailability of flavonoids Eur J Clin Nutr 1997 51: S66–S69.
Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J . Efficacy of a green tea extract rich in catechin-polyphenols and caffeine in stimulating 24 h energy expenditure and fat oxidation in humans Am J Clin Nutr (in press).
Acknowledgements
We thank D Rohrer for excellent technical support, and R Schumacher for the illustrations. This work was supported in part by Arkopharama laboratories (Nice, France) and in part by grant no. 31-47211.96 of the Swiss National Science Research Fund
Author information
Authors and Affiliations
Institute of Physiology, University of Fribourg, Fribourg, Switzerland
AG Dulloo
Department of Physiology, University of Geneva, Geneva, Switzerland
J Seydoux&L Girardier
Laboratoires Arkopharma, Nice, France
P Chantre&J Vandermander
Authors
- AG Dulloo
View author publications
You can also search for this author in PubMedGoogle Scholar
- J Seydoux
View author publications
You can also search for this author in PubMedGoogle Scholar
- L Girardier
View author publications
You can also search for this author in PubMedGoogle Scholar
- P Chantre
View author publications
You can also search for this author in PubMedGoogle Scholar
- J Vandermander
View author publications
You can also search for this author in PubMedGoogle Scholar
Corresponding author
Correspondence to AG Dulloo.
Rights and permissions
About this article
Cite this article
Dulloo, A., Seydoux, J., Girardier, L. et al. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes 24, 252–258 (2000). https://doi.org/10.1038/sj.ijo.0801101
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0801101
Keywords
- obesity
- catecholamines
- thermogenesis
- brown adipose tissue
- caffeine
This article is cited by
-
Effect of tea catechins with caffeine on energy expenditure in middle-aged men and women: a randomized, double-blind, placebo-controlled, crossover trial
- Shun Katada
- Aya Yanagimoto
- Yoshihisa Katsuragi
European Journal of Nutrition (2020)
-
Hypericum perforatum L.: a medicinal plant with potential as a curative agent against obesity-associated complications
- Hilal Büşra Tokgöz
- Filiz Altan
Molecular Biology Reports (2020)
-
Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers
- Xuejun Zhang
- Xin Li
- Shilong Huang
Nutrition & Metabolism (2019)
-
The contribution of Swiss scientists to the assessment of energy metabolism
- Jean-Pierre Montani
- Yves Schutz
- Abdul G. Dulloo
European Journal of Clinical Nutrition (2018)
-
Theobromine, a Methylxanthine in Cocoa Bean, Stimulates Thermogenesis by Inducing White Fat Browning and Activating Brown Adipocytes
- Myeong Hwan Jang
- Nam Hyeon Kang
- Jong Won Yun
Biotechnology and Bioprocess Engineering (2018)